منابع مشابه
The calcium paradox.
Much of the present knowledge of the heart’s physithat the electronmicroscopic changes in ‘‘stone heart’’ (a ology is derived from experiments with isolated perfused dreaded and lethal complication of heart surgery) was hearts. Usually based on the technique of Langendorff. It identical to the changes observed in the calcium paradox. was, and largely still is, a logic defying problem that the W...
متن کاملCalcium, sodium, and the calcium paradox.
The effect of "sodium loading," of verapamil and of nifedipine on the gain in calcium and sodium, and on the loss of myoglobin, during the calcium paradox in adult rat hearts was examined. Raising cell sodium from 56.5 +/- 2.6 to 129.5 +/- 10.2 mumol sodium/gram dry weight did not alter the degree or rate of calcium gain or myoglobin release during calcium repletion after long periods (greater ...
متن کاملAnother calcium paradox?
In a number of important diseases, the clinical course is defined principally by the host response, more so than by the initiating environmental insult. Clinicians rely on identification of this host response for diagnosis and may select those responses as targets for therapeutic intervention. Atherosclerosis is one such disease. The clinical course was once felt to result from progressive accu...
متن کاملHyperparathyroidism and the calcium paradox of aldosteronism.
BACKGROUND Aldosteronism may account for oxi/nitrosative stress, a proinflammatory phenotype, and wasting in congestive heart failure. We hypothesized that aldosterone/1% NaCl treatment (ALDOST) in rats enhances Ca2+ and Mg2+ excretion and leads to systemic effects, including bone loss. METHODS AND RESULTS At 1, 2, 4, and 6 weeks of ALDOST, we monitored Ca2+ and Mg2+ excretion, ionized [Ca2+]...
متن کاملContracture and the calcium paradox in the rat heart.
The role of contracture in the manifestation of calcium paradox-induced damage was examined using 2,3-butanedione monoxime (BDM) to inhibit myofibrillar activity. Calcium and sodium gain, loss of intracellular components, and changes in structure were monitored. If 30 mM BDM was added at the time of calcium repletion after 10 minutes of calcium-free perfusion, some protection was afforded, part...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2000
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(99)00323-5